Question

Which of the following condition will be observed in a person suffering from sickle cell anemia?

	DNA	mRNA	Amino acid at $6^{th}$ position of $\beta$ chain
A	CTC	GAG	Valine
B	CAC	GUG	Glutamic acid
C	CTC	GAG	Glutamic acid
D	CAC	GUG	Valine

• A. A
• B. B
• C. C
• D. D

Answer 1

Answer: (D)

In sickle cell anemia the codon, instead of the normal codon GAG, the messenger RNA will contain the codon GUG. This in turn will result in a mistake during translation. In a healthy individual the codon GAG on the messenger RNA matches with the anticodon CUC on the transfer RNA carrying the amino acid glutamic acid. However, if the mutated gene is present then GUG on the messenger RNA matches with the anticodon CAC on the transfer RNA which carries the amino acid valine