When cell has stalled DNA replication fork, which checkpoint should be predominantly activated ?

Question

When cell has stalled DNA replication fork, which checkpoint should be predominantly activated ? (A) G1/S (B) G2/M (C) M (D) Both G2/M and M

Tardigrade Admin · Accepted Answer

Stalled forks activate checkpoint signaling and pause replication. Since, G1/S checkpoint checks DNA damage, cells size prior to S-phase (i.e. DNA replication phase). This checkpoint would be activated by stalled DNA replication fork.

Q. When cell has stalled DNA replication fork, which checkpoint should be predominantly activated ?

G₁/S

G₂/M

M

Both G₂/M and M

Stalled forks activate checkpoint signaling and pause replication. Since, G1/S checkpoint checks DNA damage, cells size prior to S-phase (i.e. DNA replication phase). This checkpoint would be activated by stalled DNA replication fork.