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Biology
When cell has stalled DNA replication fork, which checkpoint should be predominantly activated ?
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Q. When cell has stalled DNA replication fork, which checkpoint should be predominantly activated ?
NEET
NEET 2016
Cell Cycle and Cell Division
A
G
1
/S
36%
B
G
2
/M
50%
C
M
5%
D
Both G
2
/M and M
9%
Solution:
Stalled forks activate checkpoint signaling and pause replication. Since, G1/S checkpoint checks DNA damage, cells size prior to S-phase (i.e. DNA replication phase). This checkpoint would be activated by stalled DNA replication fork.