Question

Net products of glycolysis are

• A. $2pyruvicacid+2ATP+2NAD{H}_2$
• B. $2pyruvicacid+2NAD{H}_2$
• C. $1pyruvicacid+2ATP+2NAD{H}_2$
• D. $2pyruvicacid+1ATP+1NAD{H}_2$

Answer 1

Answer: (A)

In glycolysis, two molecules of ATP are consumed during two phosphorylation reactions to form fructose $1,6-$ biphosphate. In return four molecules of ATP are produced by substrate level phosphorylation (conversion of $1,3$ -biphosphoglycerate to $3$ -phosphoglycerate and phosphoenol pyruvate to pyruvate). Two molecules of NADH₂ are formed at the time of oxidation of glyceraldehyde $3$ -phosphate to $1,3$ -biphosphoglycerate. The net reaction of glycolysis is as follows:
$Glucose+2NA{D}^{+}2ADP+2H_{3}P{O}_4\to 2Pyruvate+2NADH+2H^{+}+2ATP$
Each NADH is equivalent to $3ATP$ , so the net gain in glycolysis is $8ATP$ .