Question

Net products of glycolysis are

• A. $2 \, pyruvic \, acid+2 \, ATP+2NADH_{2}$
• B. $2 \, pyruvic \, acid+2NADH_{2}$
• C. $1 \, pyruvic \, acid+2 \, ATP+2NADH_{2}$
• D. $2 \, pyruvic \, acid+1 \, ATP+1NADH_{2}$

Answer 1

Answer: (A)

In glycolysis, two molecules of ATP are consumed during two phosphorylation reactions to form fructose $1, \, 6-$ biphosphate. In return four molecules of ATP are produced by substrate level phosphorylation (conversion of $1, \, 3$ -biphosphoglycerate to $3$ -phosphoglycerate and phosphoenol pyruvate to pyruvate). Two molecules of NADH₂ are formed at the time of oxidation of glyceraldehyde $3$ -phosphate to $1, \, 3$ -biphosphoglycerate. The net reaction of glycolysis is as follows:
$Glucose+2NAD^{+}2ADP+2H_{3}PO_{4} \rightarrow 2 \, Pyruvate+2NADH+2H^{+}+2ATP$
Each NADH is equivalent to $3 \, ATP$ , so the net gain in glycolysis is $8 \, ATP$ .