Question

How genetic and physical maps were generated in $HGP$?

• A. By using DNase
• B. By using RNase
• C. By using restriction endonuclease
• D. By using automated DNA sequences

Answer 1

Answer: (C)

For generating genetic and physical maps, restriction endonuclease was used. For sequencing the human DNA, the entire DNA from a cell is isolated and converted into random fragments of relatively smaller size by using restriction endonuclease enzyme and cloned in suitable host using specialised vectors.