Question

A simple mechanism for enzyme-catalyzed reaction is given by the following set of equations

This is known as the Michaelis-Menten mechanism. The potential energy diagram is shown in the fig. Which of the following sets of identifications is correct? (Assume that the temperature and pressure are constant).

	(1)	(2)	(3)	(4)
(a)	E+P	EP	ES	E+S
(b)	ES	Activated complex	EP	Activated complex
(c)	Ep	Activated complex	ES	Activated complex
(d)	E+S	ES	EP	E+P

• A. a
• B. b
• C. c
• D. d

Answer 1

Answer: (D)

Intermediate and product have less potential energy than activated complex