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  4. Reactivity of acid derivatives towards acyl substitution reaction is

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Q. Reactivity of acid derivatives towards acyl substitution reaction is

AMUAMU 2011

Solution:

The reactivity of acid derivatives towards nucleophilic acyl substitution reactions decreases in the following order $R C O C l>(R C O)_{2} O>R C O O R>R C O N H_{2}$ as the basicity of the leaving group increases as ie, $Cl ^{-}< RCOO ^{-}< RO ^{-}< NH _{2}^{-}$