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Q. $DNA$ is a polymer of nucleotides which are linked to each other by $3'-5'$ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?

Molecular Basis of Inheritance

Solution:

If $3' OH$ group is removed/replaced in deoxyribose, there will be no formation of phosphodiester bonds and hence polymerisation of nucleotides will be prevented.