Question

Correct sequence for reactivity of acid derivative is
(1) $\left(R C O_{2} O\right)$
(2) $R C O C l$
(3) $R C O O R$
(4) $RCONH _{2}$

• A. $2>1>3>4$
• B. $1>2>3>4$
• C. $2>1>4>3$
• D. $1>3>2>4$

Answer 1

Answer: (A)

Reactivity of acid derivatives depends on nature of leaving groups. The leaving group order is $-Cl>-OCOR>-OR>-NH_{2}$