Which reagent can be used for the alkylation of aromatic nitro compounds?

Question

Which reagent can be used for the alkylation of aromatic nitro compounds? (A) Methyl-sulphonyl carbanion (B) Methyl-iodide (C) Dimethyl-sulphate (D) Methyl-lithium

Tardigrade Admin · Accepted Answer

The NO2 group is ring deactivating group. Hence, it does not favour electrophilic alkylation in benzene. Nitrobenzene undergoes nucleophilic alkylation by carbanion intermediate. Hence, methyl sulphonyl carbanion is used for the alkylation of aromatic nitro compounds.

Q. Which reagent can be used for the alkylation of aromatic nitro compounds?

Methyl-sulphonyl carbanion

Methyl-iodide

Dimethyl-sulphate

Methyl-lithium

The $N O_{2}$ group is ring deactivating group. Hence, it does not favour electrophilic alkylation in benzene. Nitrobenzene undergoes nucleophilic alkylation by carbanion intermediate. Hence, methyl sulphonyl carbanion is used for the alkylation of aromatic nitro compounds.

Q. Which reagent can be used for the alkylation of aromatic nitro compounds?

Methyl-sulphonyl carbanion

Methyl-iodide

Dimethyl-sulphate

Methyl-lithium

The NO2​ group is ring deactivating group. Hence, it does not favour electrophilic alkylation in benzene. Nitrobenzene undergoes nucleophilic alkylation by carbanion intermediate. Hence, methyl sulphonyl carbanion is used for the alkylation of aromatic nitro compounds.

The $N O_{2}$ group is ring deactivating group. Hence, it does not favour electrophilic alkylation in benzene. Nitrobenzene undergoes nucleophilic alkylation by carbanion intermediate. Hence, methyl sulphonyl carbanion is used for the alkylation of aromatic nitro compounds.