1. Tardigrade
  2. Question
  3. Biology
  4. Which one of the following hydrolysis internal phosphodiester bonds in a polynucleotide chain?

Q. Which one of the following hydrolysis internal phosphodiester bonds in a polynucleotide chain?

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Solution:

DNA ase (or deoxyribonuclease) or simply nuclease is an enzyme which breaks down DNA by hydrolysis of the phosphodiester bonds of its sugar-phosphate back-bone. Depending on the position of hydrolysing phosphodiester bonds, nucleases are of two types:
(i) Endonucleases
(ii)Exonucleases.
Endonucleases hydrolyse phosphodiester bonds in a polynucleotide chain (i.e., DNA). While exonucleases hydrolyse terminal phosphodiester bonds in a polynucleotide chain (i.e., DNA).