Q.
Which of the following step of translation does not consume a high energy phosphate bond?
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AIPMTAIPMT 1997Molecular Basis of Inheritance
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Solution:
Protein synthesis or translation consists of ribosomes, amino acids, mRNA, tRNAs and aminoacyl tRNA synthetases. The ribosomes have two binding sites namely aminoacyl site or A-site and peptide site or P-site. The starting amino acid methionine lies at the P-site of the ribosome. The next incoming tRNA is called amino acyl tRNA, it is bound to A-site. A peptide bond is formed between COOH group of the t-RNA at P-site and NH, group of aminoacyl t-RNA. This is facilitated by the enzyme peptidyl transferase and does not require high energy phosphate bonds.