Question

Which of the following statements is/are correct about
Adenosine Deaminase (ADA) deficiency?
I. In the absense of adenosine deaminase enzyme, purine metabolism is disturbed and erythrocytes fail to function.
II. ADA deficiency is caused by the deletion of the gene for ADA.
III. ADA patients can be permanently cured by bone marrow transplantation and enzyme replacement therapy.
IV. For permanent cure, the genes isolated from the bone
marrow cells producing ADA is introduced into cells at early embryonic stages and replaced with faulty genes.

• A. I, II and III
• B. II and IV
• C. I, III and IV
• D. None of these

Answer 1

Answer: (B)

Statements II and IV are correct. Statements I and III are incorrect and can be corrected as
• In the absence of adenosine deaminase enzyme, purine metabolism is disturbed and T-lymphocytes fail to function.
• Bone marrow transplantation and enzyme replacement therapy are not permanent cures of $ADA$ deficiency.