Question

Which of the following reactions is/are correct regarding the preparation of ketone?

• A. Treatment of acyl chlorides with dialkyl cadmium, prepared by the reaction of cadmium chloride with Grignard reagent, gives ketones
• B. When benzene or substituted benzene is treated with acid chloride in the presence of anhydrous aluminium chloride, it gives the corresponding ketone. This reaction is known as Friedel-Craft's acylation reaction
• C. Treating a nitrile with Grignard reagent followed by hydrolysis yields a ketone
• D. All of the above

Answer 1

Answer: (D)

Treatment of acyl chlorides with dialkyl cadmium, prepared by the reaction of cadmium chloride with Grignard reagent, gives ketones.
$2R-Mg-X+CdC{l}_2⟶R_{2}Cd+2Mg(X)Cl$
$2R^{\prime }-COCl+R_{2}Cd⟶2R^{\prime }-COR+CdC{l}_2$
Treating a nitrile with Grignard reagent followed by hydrolysis yields a ketone.

When benzene or substituted benzene is treated with acid chloride in the presence of anhyd. $AlC{l}_3$ it gives the corresponding ketone. This reaction is known as Friedel-Craft, acylation reaction.