During mitosis, all the chromosomes behave independently while during meiosis, homologous chromosomes pair up through synapsis and form bivalents in zygotene substage of prophase-I, then in pachytene substage, crossing over occurs between homologous chromosomes and during diplotene substage of prophase-I of meiosis chiasma formation takes place. During Anaphase of both mitosis and meiosis, chromatids are separated and pulled towards opposite poles.