Which of the following factors raise the P 50 value and shifts the HbO 2 dissociation curve to right and vice versa ? (1) Rise in PCO 2 (2) Rise in H +ions (= fall in pH ) (3) Fall in temperature (4) Fall in diphosphoglyceric acid

Question

Which of the following factors raise the P 50 value and shifts the HbO 2 dissociation curve to right and vice versa ? (1) Rise in PCO 2 (2) Rise in H +ions (= fall in pH ) (3) Fall in temperature (4) Fall in diphosphoglyceric acid (A) 1, 2 and 3 are correct (B) 1 and 2 are correct (C) 2 and 4 are correct (D) 1 and 3 are correct

Tardigrade Admin · Accepted Answer

A rise in body temperature, concentration of 2,3 diphosphoglycerate (DPG) in RBCs or P CO 2, or a fall in blood pH (increase .H +), decreases O 2-affinity of haemoglobin revising P50 and shifting the O 2-haemoglobin dissociation curve to the right.

Q. Which of the following factors raise the $P_{50}$ value and shifts the $H b O_{2}$ dissociation curve to right and vice versa ?
(1) Rise in $PC O_{2}$
(2) Rise in $H^{+}$ ions (= fall in $p H$ )
(3) Fall in temperature
(4) Fall in diphosphoglyceric acid

1, 2 and 3 are correct

1 and 2 are correct

2 and 4 are correct

1 and 3 are correct

A rise in body temperature, concentration of $2, 3$ diphosphoglycerate (DPG) in $RBC s$ or $P_{C O_{2}}$ , or a fall in blood $p H$ (increase $H^{+})$ , decreases $O_{2}$ -affinity of haemoglobin revising $P_{50}$ and shifting the $O_{2}$ -haemoglobin dissociation curve to the right.

Q. Which of the following factors raise the P50​ value and shifts the HbO2​ dissociation curve to right and vice versa ? (1) Rise in PCO2​ (2) Rise in H+ions (= fall in pH ) (3) Fall in temperature (4) Fall in diphosphoglyceric acid