Question

Which of the following conversions involve ATP synthesis during glycolysis?

• A. Glucose - Glucose -6-phosphate
• B. Fructose-6-phosphate -Fructose-1, 6-biphosphate
• C. 1, 3-bisphosphogiyceric acid (BPGA) - 3- phosphoglyceric acid (PGA)
• D. All of these

Answer 1

Answer: (C)

In the energy conserving phase of glycolysis, the conversion of $BPGA$ to $PGA$ is catalysed by phosphoglycerate kinase. The phosphate on carbon 1 is transferred to a molecule of $ADP$, yielding $ATP$ and 3 -phosphoglycerate. This type of $ATP$ synthesis, traditionally referred to as substrate-level phosphorylation, involves the direct. transfer of a phosphate group from a substrate molecule to $ADP$, to form ATP .1,3 bisphosphoglycerate + ADP $\underset{M{g}^{2+}}{\overset{\text{Phosphoglycerate kinase}}{\to }}3,6$ - phosphoglycerate +ADP