Question

Which of thèse will produce the highest yield in Friedel Crafts reaction?

• A.
• B.
• C.
• D.

Answer 1

Answer: (B)

Aniline reacts with Lewis acid $(AlC{l}_3)$ to form anilinium complex.



As in the toluene $-{\text{CH}}_{\text{3}}$ group is ring activating so toluene is most reactive among these for electrophilic substitution reaction. Chlorobenzene and benzamide do not give product in good yield for this reaction as -Cl and $-CON{H}_2$ are deactivating groups.