Which o f the following cannot be made by using Williamson’s synthesis?

Question

Which o f the following cannot be made by using Williamson’s synthesis? (A) Methoxybenzene (B) Benzyl p-nitrophenyl ether (C) Methyl tertiary butyl ether (D) Di-tert-butyl ether

Tardigrade Admin · Accepted Answer

The two components should be ( CH 3)3 CONa + ( CH 3)3 CBr. However, tert-alkyl halides tend to undergo elimination reaction rather than substitution leading to the formation of an alkene, Me 2 C = CH 2

Q. Which o f the following cannot be made by using Williamson’s synthesis?

Methoxybenzene

Benzyl p-nitrophenyl ether

Methyl tertiary butyl ether

Di-tert-butyl ether

The two components should be $(C H_{3})_{3} CON a + (C H_{3})_{3} CB r$ . However, tert-alkyl halides tend to undergo elimination reaction rather than substitution leading to the formation of an alkene, $M e_{2} C = C H_{2}$

Q. Which o f the following cannot be made by using Williamson’s synthesis?

Methoxybenzene

Benzyl p-nitrophenyl ether

Methyl tertiary butyl ether

Di-tert-butyl ether

The two components should be (CH3​)3​CONa+(CH3​)3​CBr. However, tert-alkyl halides tend to undergo elimination reaction rather than substitution leading to the formation of an alkene, Me2​C=CH2​

The two components should be $(C H_{3})_{3} CON a + (C H_{3})_{3} CB r$ . However, tert-alkyl halides tend to undergo elimination reaction rather than substitution leading to the formation of an alkene, $M e_{2} C = C H_{2}$