In human beings, after one month of pregnancy, the embryo’s heart is formed. The first sign of growing foetus may be noticed by listening to the heart sound carefully through the stethoscope. By the end of the second month of pregnancy, the foetus develops limbs and digits. By the end of 12 weeks (first trimester), most of the major organ systems are formed, for example, the limbs and external genital organs are well-developed.