The equation of the chord, having mid-point as (x1,y1), of the hyperbola a2x2−b2y2=1 is given by T=S1...(i)
where, T=a2xx1−b2yy1−1 and S1=a2x12−b2y12−1
According to the question, (x1,y1)=(5,3) and a2=16,b2=25
as 25x2−16y2=400 ⇒16x2−25y2=1∴165x−253y=1625−259[Using(i)] ⇒125x−48y=625−144⇒125x−48y=481