The endocrine pancreas consists of ‘Islets of Langerhans’. There are about 1 to 2 million Islets of Langerhans in a normal human pancreas representing only 1 to 2 percent of the pancreatic tissue. The two main types of cells in the Islet of Langerhans are called alpha-cells, beta-cells, delta cells and PP cells. The alpha-cells secrete a hormone called glucagon, while the beta-cells secrete insulin. Delta cells producing somatostatin (3-10%), while PP cells (gamma cells) producing pancreatic polypeptide