Q. Renin-angiotensin pathway mainly controls
Solution:
Solution:
The JGA (juxtaglomerular apparatus) plays a complicated regulatory position. A fall in glomerular blood pressure/GFR (glomerular filtration rate) can set off the JG cells to secrete renin, leading to the conversion of angiotensinogen in the blood to angiotensin I and further to angiotensin II. The latter conversion is carried out with the help of angiotensin converting enzyme. As a powerful vasoconstrictor, angiotensin II increases the glomerular blood pressure and, thereby GFR. Angiotensin II additionally activates the adrenal cortex to release aldosterone, which facilitates the reabsorption of Na+ and water from the distal parts of the tubule; this also increases the blood pressure and consequently, the GFR. This complex process of renal blood flow regulation is generally referred to as the Renin-Angiotensin-Aldosterone (RAAS) mechanism.