Question

Other than $DNA$ polymerase, which of the following enzymes involved in $DNA$ synthesis?

• A. Topoisomerase
• B. Helicas
• C. $RNA$ primase
• D. All of these

Answer 1

Answer: (D)

Process of $DNA$ synthesis whereby a parent $DNA$ molecule is faithfully copied, giving rise to two identical daughter molecules is called $DNA$ replication. In $DNA$ synthesis, $DNA$ polymerase plays an important role having the capability to elongate an existing $DNA$ strand but cannot initiate the synthesis. So, the synthesis is initiated with the help of $RNA$ primer formed by $RNA$ primase. RNA primase synthesises the short $RNA$ primer of about $10$ nucleotides that is elongated by $DNA$ polymerase to form an Okazaki fragment of $DNA$ during $DNA$ replication. Helicase unzips the two strands of $DNA$ and topoisomerase reduces the coiling tension developed due to the unwinding of the two strands.