Protobionts are prebiotic chemical aggregates having one or more properties of living systems. Microspheres are small spheroidal biochemical aggregates with covering membrane. Microspheres formed, when a mixture of organic compounds was mixed with cool water. The covering membrane can be of the lipid bilayer if the mixture contains lipids and corresponding to cell membrane. Sidney Fox (1950) heated a dry mixture of ammo acids to 130∘−180∘C . It formed proteins or polypeptides. The latter were cooled in water. It produced protenoid microspheres of 1−2μm diameter which. could grow, constrict and divide.