Question

In the Hofmann's method for separation of $1^{\circ },2^{\circ }$ and $3^{\circ }$ amines, the reagent used is

• A. acetyl chloride
• B. benzene sulphonyl chloride
• C. diethyl oxalate
• D. nitrous acid.

Answer 1

Answer: (C)

The mixture of three amines is treated with diethyl oxalate (Hofmann's reagent). The primary amine forms a solid dialkyl oxamide, a secondary amine gives a liquid oxamic ester while tertiary amine does not react.