1. Tardigrade
  2. Question
  3. Biology
  4. In sickle cell anaemia, glutamic acid is replaced by valine. Which one of the following triplets codes for valine?

Q. In sickle cell anaemia, glutamic acid is replaced by valine. Which one of the following triplets codes for valine?

 1755  220 NTA AbhyasNTA Abhyas 2020Principles of Inheritance and Variation Report Error

Solution:

Sickle cell anaemia is caused by a mutation in the hemoglobin-beta gene found on chromosome 11. The defect is caused by the substitution of glutamic acid (Glu) by valine (Val) at the sixth position of the beta-globin chain of the haemoglobin molecule. The substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta-globin gene from GAG to GUG.