In Drosophila XXY leads to femaleness. Because Y-chromosomes has no contribution in 4 femaleness. Sex in Drosophila is determined by sex chromosome-X and autosome A. While in human XXY condition will lead to genetically male with under developed testes and a zoospermia. It is 4 caused by the union of a non-disjunction XX egg and normal X egg and abnormal XY sperm. It indicates that in human being Y-chromosome is a active in sex determination.