The Plasmodium species during malarial formation, metabolize hemoglobin and other RBC proteins to create a toxic pigment called hemozoin. Haemozoin is a waste product formed when the parasite digests the blood. The parasite digests the hemoglobin of the blood and release high quantities of free heme. This heme released is a non-protein component of hemoglobin. The haemozoin is, therefore, a product of the erythrocyte lysis released from the food vacuole into circulation.