There are 12 letters, of which N appears 3 times, E appears 4 times and D appears 2 times and the rest all are different.
Therefore, the required number of arrangements =3!4!2!12!=1663200.
Let us fix P at the extreme left position, we then count the arrangements of the remaining 11 letters. Therefore, the required number of words starting with P are =3!2!4!11!=138600.