Q.
During CO2 transport, HCO3− diffuses from erythrocytes to plasma and in turn upsets the ionic balance momentarily. In order to keep the ionic balance, an equal number of Cl− pass into the erythrocytes from plasma. The process is known as
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Breathing and Exchange of Gases
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Solution:
About 70% of CO2 is converted to bicarbonate ions (HCO3−) and transported in plasma. CO2 diffuses into RBCs, combines with water and forms carbonic acid (H2CO3). H2CO3 being unstable quickly dissociates into H+ and HCO3. HCO3 ions are quite diffusible. Therefore, HCO3− diffuses from RBCs into the plasma. To maintain the ionic balance Cl− ions move from the plasma into the RBCs. This exchange is called chloride shift or Hamburger's phenomenon.