Question

At what stage of the cell cycle are histone proteins synthesised in a eukaryotic cell?

• A. During entire prophase
• B. During telophase
• C. During S-phase
• D. During $G_2$-stage of prophase

Answer 1

Answer: (C)

During S phase of the cell cycle, the histone proteins are synthesized in a eukaryotic cell. The major event in S phase is DNA replication. The goal of this process is to create exactly two identical semi-conserved chromosomes. The cell prevents more than one replication from occurring by loading pre-replication complexes onto the DNA at replication origins during $G_1$ phase which is dismantled in $S$ phase as replication begins.