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  4. Which one of the factors are required for the maturation of erythrocytes ?

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Q. Which one of the factors are required for the maturation of erythrocytes ?

AIPMTAIPMT 1998Digestion and Absorption

Solution:

Vitamin B12 (also called cyanocobalamine) is essential for the formation and maturation of erythrocytes. Vitamin $B_{12}$ is manufactured only by micro-organisms and natural sources are entirely of animal origin. One form of vitamin $B_{12}$ functions as a coenzyme in a number of reactions, including the oxidation of fatty acids and the synthesis of DNA. It also works in conjunction with folic acid in the synthesis of the amino acid methionine and it is required for normal production of red blood cells. Vitamin A is required for maintenance of epithelia, growth and is a part of visual pigments. Vitamin C play a role in collagen formation. Vitamin D facilitates absorption of calcium and phosphorus by intestine and their retention in the body and deposition in bones.