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Q. Which of the following statements concerning the regulatory genes (R), associated with the lac operon are incorrect?
I. $m$ RNA is transcribed from the $R$ gene whether lactose is present or not.
II. $m$ RNA is transcribed from the $R$ gene only when the lactose is present.
III. $m$ RNA is transcribed from the $R$ gene only when the lactose is not present.
IV. Lactose inhibits the translation of $R$ gene $m$ RNA.

Molecular Basis of Inheritance

Solution:

Statement II, III and IV are incorrect and only statement I is correct.
This can be explained as in lac operon model, regulatory gene is continuously working, whether lactose (inducer) is present or not. It transcribes $m RNA$ which codes for repressor.
When this repressor binds with lactose (inducers) it inhibits translation of operator gene (not R gene).
Thus, lactose presence affects operator gene not $R$ gene.