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  4. Which of the following is the key intermediate compound linking glycolysis to the Krebs' cycle?

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Q. Which of the following is the key intermediate compound linking glycolysis to the Krebs' cycle?

AIPMTAIPMT 1997Respiration in Plants

Solution:

During glycolysis pyruvic acid is produced from glucose and is oxidatively decarboxylated to form acetyl CoA. This formation of acetyl CoA from pyruvic acid needs a multienzyme complex and 5 essential cofactors, i.e. lipoic acid, CoA, Mg2+, NAD and TPP (thiamine pyrophosphate). It results in production of 2 molecules of CO2 and 2 molecules of NADH2. This acetyl CoA enters mitochondria and is completely oxidised during Krebs' cycle. Thus acetyl CoA acts as the linker of glycolysis and Krebs' cycle.