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  4. Which of the following is most reactive towards nucleophilic substitution reaction?

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Q. Which of the following is most reactive towards nucleophilic substitution reaction?

NTA AbhyasNTA Abhyas 2020

Solution:

The order of reactivity of acid derivatives towards different reactions decreases in the order,

$R C O C l>(R C O)_{2} O>R C O O R^{\prime}>R C O N H_{2}$

In other words, the reactivity decreases as the basicity of the leaving group increases i.e.,

$Cl^{-} < RCOO^{-} < RO^{-} < NH_{2}^{-}$