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  4. Which of the following inhibits protein synthesis by binding to 50S ribosome?

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Q. Which of the following inhibits protein synthesis by binding to $50S$ ribosome?

Molecular Basis of Inheritance

Solution:

Erythromycin and other macrolide antibiotics inhibit protein synthesis by binding to the $23S$ $r RNA$ molecule (in the $50S$ subunit) of the bacterial ribosome blocking the exit of the growing peptide chain. The association between erythromycin and the ribosome is reversible and takes place only when the $50S$ subunit is free from $t RNA$ molecules bearing nascent peptide chains.