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  4. Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?

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Q. Which antibiotic inhibits interaction between $ tRNA $ and $ mRNA $ during bacterial protein synthesis?

ManipalManipal 2012

Solution:

Tetracycline interferes with the attachment of $ tRNA $ carrying the amino acid to the mRNA-ribosome complex preventing the addition of amino acids to the growing polypeptide chain. Streptomycin interferes with the initial steps of protein synthesis by changing the shape of $30\, S$ proton of $70\,S$ prokaryotic ribosome. Erythromycin reacts with $50\, S$ portion of the $70\, S$ prokaryotic ribosome.