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Q.
Urea synthesis takes place primarily in liver because
Delhi UMET/DPMTDelhi UMET/DPMT 2010
Solution:
Urea synthesis takes place in liver through ornithine cycle. In liver, one molecule of $CO _{2}$ is activated by biotin and combines with two molecules of $NH _{3}$ in the presence of carbamyl phosphate synthetase enzyme and $2$ ATP to form carbamyl phosphate and one molecule of $H _{2} O$ is released. Carbamyl phosphate react with ornithine arid form citrulline that combines with another molecule of $NH _{3}$ and form argininee. Arginme is broken into urea and ornithine in the presence of an enzyme arginase and water.