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  3. Chemistry
  4. The pKa of acetyl salicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is around 2 and the pH in small intestine is around 8. Aspirin will be

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Q. The $ p{{K}_{a}} $ of acetyl salicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is around 2 and the pH in small intestine is around 8. Aspirin will be

AMUAMU 1997

Solution:

: Aspirin is a weak monoprotic acid. In the stomach, the medium is acidic while in the small intestine, the medium is basic. Hence acetyl salicylic acid is almost unionized in stomach but ionized in the small intestine.