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  4. The enzyme responsible for oxidative decarboxylation of pyruvate to acetyl Co-A is

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Q. The enzyme responsible for oxidative decarboxylation of pyruvate to acetyl Co-A is

NTA AbhyasNTA Abhyas 2020Respiration in Plants

Solution:

Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters the mitochondrial matrix undergoes oxidative decarboxylation by a complex set of reactions catalyzed by pyruvic dehydrogenase. The reactions catalyzed by pyruvic dehydrogenase require the participation of several coenzymes, including NAD+ and Coenzyme A. During this process, two molecules of NADH are produced from the metabolism of two molecules of pyruvic acid (produced from one glucose molecule during glycolysis).