1. Tardigrade
  2. Question
  3. Biology
  4. Sickle cell anaemia is caused by the substitution of Glu by at the sixth position of the beta-globin chain of the haemoglobin molecule.

Question Error Report

Thank you for reporting, we will resolve it shortly

Back to Question

Q. Sickle cell anaemia is caused by the substitution of Glu by ________ at the sixth position of the beta-globin chain of the haemoglobin molecule.

NTA AbhyasNTA Abhyas 2020Principles of Inheritance and Variation

Solution:

Sickle cell anaemia is an example of point mutation in which base substitution occurs in beta chain of haemoglobin. At sixth position amino acid is glutamic acid specified by codon GAG, mutation results in change in codon to GUG which specifies amino acid Valine.