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  4. Pyruvate can be converted to acetyl coA by the action of

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Q. Pyruvate can be converted to acetyl coA by the action of

UP CPMTUP CPMT 2011

Solution:

Pyruvate converts into acetyl $coA$ in the presence of pyruvate dehydrogenase enzyme complex. The pyruvate dehydrogenase complex is a multi-molecular aggregate of three enzymes - pyruvate decarboxylase, dihydrolipoyl transacetylase and dihydrolipoyl dehydrogenase. It also requires $Mg^{+2}$. This conversion is gateway step or link reaction between glycolysis and Krebs' cycle and acetyl $coA$ acts as the connecting link. The formation of acetyl $coA$ results in the production of $2$ molecules of $CO_2$ and $2$ molecules of $NADH_2$.