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  4. Mongolism or Down's syndrome occurs when the patients have

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Q. Mongolism or Down's syndrome occurs when the patients have

Principles of Inheritance and Variation

Solution:

Down's syndrome is a congenital disorder and is characterised by the mongoloid facial features, reduced life expectancy and mental retardation. It occurs due to trisomy of $21^{\text {st }}$ chromosomes. Its incidence is strongly correlated with maternal age.