Question

Match the human disorders shown in Group I with the biochemical processes in Group II. Choose the correct combination.

Group I		Group II
A	Phenylketonuria	1	Melanin synthesis
B	Albinism	2	Conversion of phenylalanine totyrosine
C	Homocystinuria	3	Tyrosine degradation
D	Argininemia	4	Methionine metabolism
		5	Urea synthesis

• A. A- (2), B- (1), C-(4), D-5
• B. A -(1), B- (4), C- (2), D-(5)
• C. A- (2), B - (1), C-(5), D-(3)
• D. A-(5), B-(3), C -(1), D-(2)

Answer 1

Answer: (A)

Phenylketonuria is caused by mutations in the gene that makes an enzyme phenylalanine hydroxylase. This enzyme is needed to convert the amino acid phenylalanine to tyrosine.
Albinism is a group of inherited disorder characterised by little or no melanin production.
Homocystinuria is a disorder of methionine metabolism, leading to an abnormal accumulation of homocysteine and its metabolites in blood and urine. Argininemia is an autosomal recessive disorder associated with urea synthesis