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  4. Lesch Nyhan disease is an X-linked recessive disorder that causes neurological damage in human beings. A survey of 500 mates from a caucasion population revealed that 20 were effected with this disorder. What is the frequency of the normal allele in this population?

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Q. Lesch Nyhan disease is an X-linked recessive disorder that causes neurological damage in human beings. A survey of $500$ mates from a caucasion population revealed that $20$ were effected with this disorder. What is the frequency of the normal allele in this population?

Principles of Inheritance and Variation

Solution:

$q^{2} \Rightarrow \frac{20}{500} $
$\Rightarrow \frac{1}{25} \Rightarrow 0.2$
$q=0.2$
$p+q=1$
$p=0.8$