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  4. In sickle cell anaemia there is deformity of:

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Q. In sickle cell anaemia there is deformity of:

J & K CETJ & K CET 2001

Solution:

Sickle cell anaemia is a biochemical disorder inherited as recessive trait. In normal haemoglobin a dominant gene codes for glutamic acid monomer at sixth position in beta chain. The recessive allele of this gene codes for the insertion of amino acid valine in place of glutamic acid at sixth position of beta chain. Such defective haemoglobin is useless for oxygen transportation.