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Q. In order to lessen the suffering of phenylketonurics their diet should have

AMUAMU 2014Principles of Inheritance and Variation

Solution:

Phenylketonuria $(PKU)$ is a disease caused by the livers inability to produce a particular type of phenylalanine hydroxylase $(PAH) $ enzyme. This enzyme converts the amino acid phenylalanine into tyrosine. A lack of $PAH$ causes buildup of abnormally high phenylalanine concentrations in the blood and brain. The typical diet prescribed for $PKU$ patients is very small amount of phenylalanine and higher quantity of tyrosine.