1. Tardigrade
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  3. Biology
  4. In E. coli, a finished polypeptide has 162 amino acids of which the first amino acid is not a methionine compound. How many nucleotides of DNA are required to code this polypeptide?

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Q. In E. coli, a finished polypeptide has $162$ amino acids of which the first amino acid is not a methionine compound. How many nucleotides of DNA are required to code this polypeptide?

ManipalManipal 2010

Solution:

There is an intimate connection between genes and synthesis of polypeptides or enzymes The relationship between the sequence, of amino acids in a polypeptide and nucleotide sequence of DNA or mRNA is called genetic code.
To code a polypeptide of $162$ amino acids $486$ nucleotides required but here, methionine is absent. Therefore, $489$ nucleotides required and methionine may remove from polypeptide later.